If "Lione" is italian for "Lyon" and you'd like to go from Milano (you didn't tell):

There's an afternoon TGV from Milano with a bus replacement in between. For Lyon, you need to change once more in Chambéry-Challes-les-Eaux. But that's not cheap if you are holding an Interrail pass but may be a good idea if you do need a normal ticket (you didn't tell).

Best idea may be to go to Genf in Switzerland and from there by direct train to Lyon. But there's a bus replacement in summer, too on the italian part. Will be cheaper if you are holding a railpass.

Avoiding any bus replacement would mean going via Lugano in Switzerland (takes about 10h). That's possible and may be an option if you are holding a railpass. 

But timetables for July aren't published yet so you need to wait anyway.

Thanks